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A recent study discovered that nonsteroidal anti-inflammatory drugs (NSAIDs) – which include aspirin, ibuprofen, and naproxen – can reduce the effectiveness of the commonly used class of antidepressant called selective serotonin-reuptake inhibitors (SSRIs), such as Prozac, Paxil, Zoloft and Celexa.
Fifteen percent fewer subjects responded to SSRIs when taking NSAIDs compared to those not on the pain pills.
If you are currently taking an SSRI and pop those over-the-counter painkillers regularly, talk to your doctor about other drug options.